Trans-ISRIB 25mg – 60 capsules (presale)

139.00€

3 Products -5%

132.05 € /pc

6 Products -10%

125.10 € /pc

8 Products -15%

118.15 € /pc

Trans-ISRIB 25 mg – 60 capsules research-grade small-molecule capsules supplied in a sealed bottle. Trans-ISRIB is the trans-isomer of ISRIB (Integrated Stress Response Inhibitor), a potent small molecule studied as an inhibitor of the PERK–eIF2α phosphorylation pathway and a tool compound for dissecting integrated stress response (ISR) signaling in cellular and central nervous system research models.

Research Use Only: All products are intended exclusively for laboratory and scientific research. Not for human or veterinary use.

Purity

High-purity research grade

Form

Research capsules

Content

25 mg Trans-ISRIB per capsule

Total count

60 capsules (total 1,500 mg per bottle)

Packaging

Sealed bottle

Storage

Store at room temperature, protect from light, keep desiccated

Molecular formula

C₂₂H₂₄Cl₂N₄O₄

Molecular weight

~495.36 g·mol⁻¹

IUPAC name

N,N’-(Azanediylbis(4,1-phenylene))bis(2-(4-chlorophenoxy)acetamide)

CAS number

1588325-24-3

Research Overview

Trans-ISRIB is the active trans-isomer of the Integrated Stress Response Inhibitor (ISRIB), used in experimental systems as a potent inhibitor of the cellular integrated stress response. In preclinical literature it is characterized as acting downstream of PERK-mediated eIF2α phosphorylation to modulate eIF2B-dependent translation control. Laboratory models employ Trans-ISRIB to study how selective interference with ISR signaling influences protein synthesis, neuronal function and adaptation to cellular stress in central nervous system and systemic stress paradigms.

Primary Research Areas

Integrated stress response (ISR) signaling: used as a tool compound to investigate how pharmacological inhibition of ISR signaling alters the PERK–eIF2α–eIF2B axis, global protein synthesis and selective translation of stress-responsive mRNAs in cellular stress models.
PERK–eIF2α phosphorylation and translation control: applied in in vitro systems to study downstream consequences of PERK activation, eIF2α phosphorylation and restoration of translation initiation, including effects on proteostasis markers and stress-adaptation pathways.
Memory and cognitive function models: incorporated into preclinical paradigms that examine how modulation of ISR signaling influences learning, memory consolidation and retrieval, synaptic efficacy and hippocampus-dependent tasks under controlled laboratory conditions.
Traumatic brain injury (TBI) and CNS injury research: used in experimental models of traumatic brain injury and related CNS insults to probe how ISR pathway modulation affects neuronal survival, circuit function and recovery-associated endpoints.
Neurodegeneration and synaptic plasticity: evaluated in models of neurodegenerative processes and synaptic plasticity, where chronic or excessive ISR activation is investigated as a mechanistic contributor to altered neuronal resilience, connectivity and network performance.

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Limitless BioChem is a trusted supplier of research compounds. Our products meet strict quality standards and are compliant with EU requirements. We focus on the safe and reliable supply of peptides and pure compounds intended exclusively for research or collector purposes.

This product is not intended for human or veterinary use. It is for collection or research purposes only. It cannot be used as food, dietary supplement or medicine! The information provided in the text on this page is for educational purposes only and does not constitute medical or other advice.