SLU-PP-332 250mcg – 60 capsules

SLU-PP-332 250 mcg – 60 capsules research-grade formulation providing 250 mcg SLU-PP-332 per capsule, in a glass bottle of 60 research capsules. SLU-PP-332 is a compound which is a potent but non-selective estrogen-related receptor (ERR) agonist, acting most strongly at ERRα with an EC50 of 98 nM. It was found to counteract metabolic syndrome in mice, suggesting a possible role for compounds from this class as medications for the treatment of obesity.

Research Overview

SLU-PP-332 is a small-molecule agonist of estrogen-related receptors (ERRα / ERRγ), nuclear receptors that play a central role in regulating mitochondrial biogenesis, oxidative metabolism, and fatty-acid utilization. Unlike stimulants or classical thermogenic agents, SLU-PP-332 does not act on the central nervous system. Instead, it reprograms metabolic gene expression in muscle and other tissues toward a highly oxidative, endurance-adapted phenotype, similar to changes observed with consistent aerobic training.

Primary Research Areas

• • Estrogen-Related Receptor (ERRα / ERRγ) activation:
    Research models examining nuclear receptor–mediated transcriptional control of oxidative metabolism, mitochondrial gene expression, and muscle fiber programming.

  • Mitochondrial biogenesis & function:
    Studies focused on mitochondrial density, respiratory capacity, electron transport chain efficiency, and adaptations associated with enhanced oxidative phosphorylation.

  • Metabolic pathways & substrate utilization:
    Investigation into fatty acid oxidation, glucose–lipid fuel switching, metabolic flexibility, and energy efficiency in skeletal muscle and peripheral tissues.

  • Exercise-mimetic & endurance-related models:
    Experimental work evaluating endurance capacity, fatigue resistance, and transcriptional profiles that resemble adaptations typically induced by aerobic training.

  • Cellular energy regulation (PGC-1α signaling):
    Research exploring downstream coactivator pathways involved in mitochondrial programming, oxidative enzyme expression, and long-term metabolic adaptation.