PNC-27 5 mg

139.00€

Availability: 132 in stock

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PNC-27 5 mg research-grade lyophilized peptide powder supplied in a glass vial. PNC-27 is a synthetic peptide construct typically combining a membrane-penetrating peptide sequence with a p53-derived HDM2/MDM2-binding domain and is studied in oncology-focused research models investigating selective cancer cell targeting and membrane-disruptive mechanisms.

Research Use Only: All products are intended exclusively for laboratory and scientific research. Not for human or veterinary use.

Purity

High-purity research grade

Form

Lyophilized peptide powder

Content

5 mg PNC-27 per vial

Packaging

Glass vial with sterile closure

Storage

Store lyophilized at 2–8 °C (desiccated, protect from light)

Molecular formula

C₂₁₄H₃₆₂N₇₀O₅₀ (representative)

Molecular weight

~4747.4 g·mol⁻¹ (representative)

Sequence / structure

(Membrane-penetrating sequence)-Linker-(p53 HDM2-binding domain sequence), e.g. RQIKIWFQNRRMKWKK-GGGSG-KKETLSPDDVQRE

CAS number

303145-71-7

In laboratory workflows, lyophilized research peptides are typically handled with suitable sterile diluents such as bacteriostatic water (BAC). For a compatible research-only solvent, see Bacteriostatic water – 10 ml .

Research Overview

PNC-27 is a synthetic peptide construct designed for oncology research. It typically comprises a membrane-penetrating peptide segment (such as an Antennapedia-derived sequence) linked to a peptide fragment corresponding to the HDM2/MDM2-binding domain of the p53 tumor suppressor protein. In experimental in vitro and in vivo models it is used to investigate how targeting membrane-associated HDM2/MDM2 on cancer cells may influence membrane integrity, p53-related pathways and selective cytotoxic responses under controlled laboratory conditions.

Primary Research Areas

Targeting membrane-bound HDM2/MDM2: used in studies examining how p53-derived peptide segments interact with HDM2/MDM2 proteins localized at the plasma membrane of cancer cells and how this targeting affects signaling and membrane structure.
Selective cytotoxicity in cancer models: applied in experimental models exploring differential effects on transformed versus non-transformed cells, with emphasis on mechanisms that may preferentially compromise cancer cell viability in vitro.
Membrane disruption and cell death pathways: incorporated into research on peptide-induced membrane perturbation, pore formation, necrotic and apoptotic signaling cascades, and associated biomarker changes in cancer cell lines.
p53-related signaling mechanisms: used as a tool to probe interactions between the p53 pathway, HDM2/MDM2 regulation and downstream transcriptional programs in oncology-focused cell and tissue models.
Preclinical oncology research models: evaluated in a variety of in vitro and in vivo systems, including pancreatic, breast and hematologic cancer models, to study tumor cell responsiveness, resistance patterns and mechanistic endpoints.

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Why Limitless Biochem?

Limitless BioChem is a trusted supplier of research compounds. Our products meet strict quality standards and are compliant with EU requirements. We focus on the safe and reliable supply of peptides and pure compounds intended exclusively for research or collector purposes.

This product is not intended for human or veterinary use. It is for collection or research purposes only. It cannot be used as food, dietary supplement or medicine! The information provided in the text on this page is for educational purposes only and does not constitute medical or other advice.