B7-33 10mg

B7-33 10 mg research-grade lyophilized peptide powder in a glass vial. B7-33 is a synthetic single-chain analog of the B-chain of human Relaxin-2, engineered to selectively activate the Relaxin Family Peptide Receptor 1 (RXFP1) in experimental models of fibrosis, cardiometabolic function and vascular biology.

Research Overview

B7-33 is a functionally selective single-B-chain analog of human Relaxin-2 designed to preferentially signal through RXFP1. In experimental models, it is used to study RXFP1-mediated ERK signaling, extracellular matrix remodeling and organ protection pathways without activating insulin or IGF receptors. Research focuses on anti-fibrotic, cardioprotective and vasoprotective mechanisms in vitro and in vivo.

Primary Research Areas

• RXFP1 receptor signaling: Studies on biased agonism at RXFP1, including ERK1/2 activation and cAMP-independent signaling profiles in relaxin receptor–expressing cells.
• Anti-fibrotic & extracellular matrix research: Experimental fibrosis models evaluating modulation of collagen deposition, matrix metalloproteinases and tissue remodeling pathways.
• Cardiovascular & vascular models: In vitro and in vivo systems investigating vasodilation, endothelial function and cardioprotective signaling under stress conditions.