BPC-157 10 mg

BPC-157 10 mg (Body Protection Compound-157) research-grade lyophilized peptide powder in a glass vial. Studied in preclinical models of tissue regeneration, angiogenesis, inflammatory signaling and gastrointestinal integrity.

Research Overview

BPC-157 (Body Protection Compound-157) is a synthetic pentadecapeptide derived from a gastric protein complex. In experimental models it is used to explore mechanisms of tissue regeneration, angiogenesis, inflammatory modulation and maintenance of gastrointestinal barrier integrity.

Primary Research Areas

• Tissue regeneration & repair: tendon, ligament, muscle and organ-healing models [1].
• Angiogenesis & microcirculation: studies on new blood-vessel formation and vascular support [2,4].
• Inflammation & cytoprotection: models of inflammatory signaling, cytoprotection and stress responses [3,6].
• Gastrointestinal & brain–gut research: experiments focused on gut barrier integrity and brain–gut axis mechanisms [3,6].
• Blood flow to healing tissue: BPC-157 relaxes blood vessels through nitric oxide, shown first in rat aorta and in 2026 in human internal mammary artery, the vessel surgeons use for coronary bypass. In rats with a blocked leg artery it also sped up the return of blood flow and increased VEGFR2, the main receptor for new vessel growth. Better blood supply is one likely reason for the healing effects seen in other models [2,4,5].
• Protection of the stomach during anti-inflammatory drugs: in rats it prevented the damage to stomach, intestine, liver and brain caused by diclofenac, given either by injection or in drinking water. [6]
• Bleeding and clotting: in rats given heparin, warfarin or aspirin, BPC-157 shortened bleeding time after amputation and limited the fall in platelets, without cancelling the anticoagulant activity of heparin. The result concerns bleeding control and an overlap with anticoagulant drugs, which has not been tested in people [7].
• Nerve and spinal cord recovery: after a crush injury of the rat spinal cord, one injection given ten minutes later improved tail movement, resolved spasticity within two weeks and reduced the loss of axons. This is the basis of the interest in recovery after nerve injury [8].

References

1. Chang CH, Tsai WC, Lin MS, et al. The promoting effect of pentadecapeptide BPC 157 on tendon healing involves tendon outgrowth, cell survival, and cell migration. J Appl Physiol (1985). 2011;110(3):774-80. PMID 21030672. doi:10.1152/japplphysiol.00945.2010
2. Hsieh MJ, Liu HT, Wang CN, et al. Therapeutic potential of pro-angiogenic BPC157 is associated with VEGFR2 activation and up-regulation. J Mol Med (Berl). 2017;95(3):323-333. PMID 27847966. doi:10.1007/s00109-016-1488-y
3. Sikiric P, Hahm KB, Blagaic AB, et al. Stable Gastric Pentadecapeptide BPC 157, Robert’s Stomach Cytoprotection/Adaptive Cytoprotection/Organoprotection, and Selye’s Stress Coping Response: Progress, Achievements, and the Future. Gut Liver. 2020;14(2):153-167. PMID 31158953. doi:10.5009/gnl18490
4. Hsieh MJ, Lee CH, Chueh HY, et al. Modulatory effects of BPC 157 on vasomotor tone and the activation of Src-Caveolin-1-endothelial nitric oxide synthase pathway. Sci Rep. 2020;10(1):17078. PMID 33051481. doi:10.1038/s41598-020-74022-y
5. Yildirim AK, Dastan AO, Demeli Ertus M, et al. Endothelium-Dependent Nitric Oxide-Mediated Vasorelaxant Effects of BPC 157 in Human Internal Mammary Artery. J Clin Med. 2026;15(9):3488. PMID 42123221. doi:10.3390/jcm15093488
6. Ilic S, Drmic D, Franjic S, et al. Pentadecapeptide BPC 157 and its effects on a NSAID toxicity model: diclofenac-induced gastrointestinal, liver, and encephalopathy lesions. Life Sci. 2011;88(11-12):535-42. PMID 21295044. doi:10.1016/j.lfs.2011.01.015
7. Stupnisek M, Franjic S, Drmic D, et al. Pentadecapeptide BPC 157 reduces bleeding time and thrombocytopenia after amputation in rats treated with heparin, warfarin or aspirin. Thromb Res. 2012;129(5):652-9. PMID 21840572. doi:10.1016/j.thromres.2011.07.035
8. Perovic D, Kolenc D, Bilic V, et al. Stable gastric pentadecapeptide BPC 157 can improve the healing course of spinal cord injury and lead to functional recovery in rats. J Orthop Surg Res. 2019;14(1):199. PMID 31266512. doi:10.1186/s13018-019-1242-6