Orexin B 5mg

Orexin B 5 mg research-grade lyophilized peptide powder in a glass vial. This hypothalamic neuropeptide (also known as Hypocretin-2, Hcrt-2) is studied in experimental models of wakefulness, sleep–wake regulation, appetite control, energy balance and reward-related signaling.

Research Overview

Orexin B is an endogenous hypothalamic neuropeptide derived from the prepro-orexin precursor and is one of the two orexin/hypocretin ligands alongside Orexin A. In experimental systems, Orexin B acts predominantly at the Orexin Receptor 2 (OX2R), where it serves as a potent agonist used to probe sleep–wake circuitry, arousal states, feeding behavior, energy homeostasis and reward-related pathways in vitro and in vivo research models.

Primary Research Areas

• Sleep–wake regulation and narcolepsy models: Used in laboratory studies investigating hypothalamic circuits that stabilize wakefulness, model narcolepsy-like phenotypes and dissect orexinergic contributions to sleep–wake transitions via OX2R signaling.
• Arousal, vigilance and stress-related arousal: Applied in experimental preparations to examine how orexinergic input modulates neuronal excitability, cortical activation and behavioral arousal under baseline and stress-related conditions.
• Appetite and energy homeostasis: Studied in preclinical feeding and metabolic models to explore the role of Orexin B in food intake, energy expenditure and integration of metabolic cues at the level of the hypothalamus.
• Reward and motivation circuitry: Employed to investigate orexinergic modulation of mesolimbic and mesocortical pathways, including reward-driven behaviors and motivational salience in rodent and in vitro systems.
• Synaptic transmission and neuronal plasticity: Used in electrophysiological and imaging studies to characterize how Orexin B influences glutamatergic signaling, neuronal firing patterns and plasticity in defined brain regions.