PE-22-28 5 mg

PE-22-28 5 mg research-grade lyophilized peptide powder in a glass vial. PE-22-28 is a synthetic heptapeptide (Gly-Val-Ser-Trp-Gly-Leu-Arg), a shortened analogue of spadin, itself derived from the sortilin propeptide (PE). It is studied as a TREK-1 (K2P2.1) potassium-channel blocker in neuroplasticity and mood-related research models.

Research Overview

PE-22-28 is a short neuroactive heptapeptide derived from spadin, itself a fragment of the sortilin propeptide (PE). In experimental neuroscience models it is used to block the TREK-1 potassium channel and to follow the downstream BDNF/TrkB signalling, hippocampal neurogenesis and neuronal-survival pathways in vitro and in vivo, without implying any therapeutic application.

Primary Research Areas

• TREK-1 channel & BDNF/TrkB signalling: Experimental models using PE-22-28 as a TREK-1 blocker to probe the downstream BDNF-related signalling cascades and kinase activation.
• Neurogenesis & synaptic plasticity: In vitro and in vivo studies examining hippocampal neurogenesis, synaptic density markers and plasticity-associated proteins under PE-22-28 exposure.
• Mood & stress-related models: Laboratory models of depression, anxiety and stress resilience evaluating how TREK-1 / TrkB pathway modulation influences behavioural and molecular readouts.